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WFH 2012 World Congress

 

8-12 July, 2012 Paris, FRANCE
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Discussion forum - WFH 2012 World Congress
    Topic - Inhibitors Pathogenesis, Prevention and Treatment

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Poster: 123
Visits: 568
Title: Genetic risk factors for inhibitor development in a Brazilian severe hemophiliaA population
Authors: Margareth Castro Ozelo ,
Centre: UNICAMP

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GENETIC RISK FACTORS FOR INHIBITOR DEVELOPMENT IN A BRAZILIAN SEVERE HEMOPHILIAA POPULATION

Margareth Ozelo
Thread initiator
Subspeciality
Reg: 6/25/2012 5:38:00 PM

Comment# 1

The formation of inhibitory alloantibodies against factor VIII (FVIII) is a severe complication of the replacement therapy in patients with hemophilia A (HA).Approximately 20-25 of patients with severe HA develop inhibitors. Both genetic and environmental factors influence the susceptibility of patients to developinhibitors. The ethnicity is a known risk factor for the development of inhibitor, with a high prevalence among African descents.Brazil has a highly heterogeneous population, and the Brazilian population has a great influence of the African ethnic group. In Brazil more than 95 of HApatients receive exclusively plasma-derived FVIII.The aim of this study is to investigate genetic factors that could influence the risk of inhibitor development in a multiracial population receiving similar FVIIIconcentrates.The prevalence of inhibitor in the Brazilian severe HA patients analyzed in this study was higher among black patients. The FVIII mutation analysisrevealed higher prev

Comment added on 6/25/2012 10:03:00 PM 
     
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Most viewed poster for this congress
Poster: 243
Visits: 2712
Title: Use of the Exergaming (Nintendo Wii) in the Rehabilitation of Patients withHemophilia.
Authors: JANAINA BOSSO JOSÉ DA SILVA , Rafael Fagnani, Egritti de Oliveira Zacarias da Silva,Marcia Aparecida Picoloto Matta, Margareth Castro Ozelo
Centre: UNICAMP

Poster most viewed in this topic
Poster: 133
Visits: 881
Title: A Canadian survey on the incidence and risk factors for inhibitor development insevere hemophilia A PUPs: 2005-2010.
Authors: Georges-Etienne Rivard , M. Carcao, C. Infante-Rivard, A.M. StainE. Paradis, J. Teitel
Centre: CHU Sainte-Justine, Montréal, QC, Canada


 
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